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  • Küçük Resim
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    Can Vitamin D reduce the need for SSRI by modulating serotonin synthesis? : a review of recent literature
    (Springer Nature, 2025) Bostan, Zekiye Zeynep; Bulut, Melike Sare; Gezmen Karadağ, Makbule
    Purpose of Review: This study aims to analyze the effects of vitamin D on serotonin synthesis, release, and function in the brain, and to explore its relationship with various psychiatric disorders. Recent Findings: The hormone calcitriol plays a vital role in regulating a multitude of biological processes within the human body. Its deficiency can lead to significant adverse effects on overall health and well-being, including physical and psychological consequences. Evidence indicates that vitamin D may exert influences through receptors in the brain, modulating serotonin production and influencing emotional and cognitive processes. Recent studies propose that elevated serum vitamin D may enhance mood and alleviate depressive states. The impact of vitamin D on cognitive function and behavior remains an area of ongoing investigation. This literature review analyses the available evidence on how vitamin D intake impacts the severity of illness and medication requirements in diverse psychiatric disorders. A review of the literature suggests that there may be a correlation between vitamin D and serotonin, which could potentially contribute to more favorable outcomes in the context of illness. Vitamin D may increase the amount of serotonin in the synaptic gap, which is the intended use of selective serotonin reuptake inhibitors (SSRIs), with its effect on the increase in serotonin release. Summary: According to reports, vitamin D supplementation in conjunction with SSRI group medication provides an additive effect for the management of psychiatric disorders.
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    Effect of plant-based diets on rheumatoid arthritis: a systematic review
    (Oxford University Press, 2025) Bostan, Zekiye Zeynep; Sare Bulut, Melike; Özen Ünaldı, Buket; Albayrak Buhurcu, Ceren; Akbulut, Gamze
    Context Rheumatoid arthritis (RA) is an autoimmune disease that leads to chronic inflammation and joint damage. Various plant-based diets are thought to have effects on RA symptoms and disease activity.Objective Relevant literature on the effect of different types of plant-based diets on RA was reviewed.Data Sources A systematic search was conducted using the Web of Science, PubMed, Scopus, and Cochrane databases and following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.Data Extraction Articles on observational and interventional human studies carried out in the adult population and published in English between February 2013 and April 2023 were eligible for inclusion. Articles reporting on studies performed in populations under 18 years of age, with unclear methods and results, or for which the full text was unavailable were excluded. The risk of bias in the selected studies was assessed using the Joanna Briggs Institute checklists.Data Analysis Of 547 screened articles, 15 were included, comprising 4 cross-sectional, 2 cohort, and 9 randomized controlled trials. These studies examined the effects of various diets, including the Mediterranean, low-fat high-carbohydrate, anti-inflammatory, and vegan, on RA. Results indicate adherence to plant-based diets generally reduced disease severity and improved dietary intake, physical activity, body weight, and key clinical markers such as the Disease Activity Score-28, Visual Analog Scale score, Health Assessment Questionnaire Disability Index, erythrocyte sedimentation rate, and C-reactive protein level in patients with in RA.Conclusions Most of the studies suggested the Mediterranean diet may positively affect the severity of RA. However, the included studies show heterogeneity. Therefore, more randomized controlled studies are needed in this area to increase understanding of the effect of diet on RA and facilitate the implementation of strategies to prevent RA.Systematic Review Registration PROSPERO registration no. CRD42023420577.
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    Kısa bağırsak sendromunda malnutrisyonun önlenmesi ve tedavisinde beslenmenin rolü: geleneksel derleme
    (Gazi Üniversitesi, 2024) Kahraman, Tuba; Bostan, Zekiye Zeynep; Samur, Gülhan
    Kısa bağırsak sendromu toplumda yaygın görülmemekle birlikte son kırk yılda prevalansında 2 kat artış olduğu düşünülen bir hastalıktır. Konjenital anomalinin türü veya uygulanan cerrahi rezeksiyona bağlı olarak farklı patofizyolojik mekanizmaların eşlik ettiği bu hastalıkta, hastaların en büyük problemlerinden biri malabsorpsiyondur. Malabsorpsiyon ve buna bağlı stoma kayıpları hastada ciddi malnütrisyon gelişme riskini doğurmaktadır. Bu durum oral beslenmenin yetersiz olduğu durumlarda ek olarak hastanın uzun dönem enteral ve/veya parenteral beslenme ile tedavi edilmesini gerektirmektedir. Hastaların metabolik ve fizyolojik koşullarına uygun beslenme gereksinimleri saptandıktan sonra yeterli enerji, protein ve mikrobesin ögelerinden zengin bir diyet içeriğinin olması tedavide elzemdir. Günlük enerji ve protein gereksinimlerini karşılamak adına 20-35 kkal/kg enerji ve 0.8-1.4 g/kg protein içeren bir diyet, konu ile ilgili uzman bir diyetisyen tarafından planlanmalıdır. Son dönemde yapılan bazı araştırmalar, probiyotik, omega-3 ve sitrulin gibi takviyelerin kısa bağırsak sendromuna ilişkin metabolik süreçlerde olumlu etkileri olduğunu ortaya koymuştur. Probiyotik çalışmalarında özellikle Lactobacillus ve Bifidobacterium gibi bakteri cinsleri ön plana çıkmıştır. Omega-3 yağ asitlerinin parenteral beslenmeye bağlı kolestaz tedavisinde etkili olabileceği ve parenteral beslenme durumunda karaciğerin yeni bir koruyucu ajanı olabileceği ortaya koyulmuştur. Sitrulin takviyesinin 0.1-3.0 mg/kg/gün doz aralığında uygulandığında bağırsak sağlığı üzerinde potansiyel etkiler geliştirebileceği saptanmıştır. Bununla beraber bu takviyelerin klinikte kullanımına ilişkin hala kanıt düzeyi yüksek klinik araştırmalara ihtiyaç vardır. Kısa bağırsak sendromu hastaları, medikal tedavi ve tıbbi beslenme tedavisi açısından multidisipliner bir ekiple takip edilmelidir.
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    Probiotics and diet quality: modulation of gut microbiota on intestinal infection and inflammation
    (Lippincott Williams and Wilkins, 2025) Bostan, Zekiye Zeynep; Biliközen Aygün, Billur; Çergel, Eda
    Inflammatory bowel disease (IBD) is a chronic inflammatory condition affecting the digestive tract. The precise etiology of IBD remains unclear; however, there is a growing body of evidence suggesting that dietary factors may play a significant role in the pathogenesis of this disease. Dietary habits exert a significant influence on the structure of the gut microbiota, which in turn plays a pivotal role in maintaining intestinal balance. Conversely, intestinal inflammation has the potential to trigger gut dysbiosis, which affects the absorption of nutrients by host cells and gut microbiota. The interaction between diet and gut microbiota is impaired in individuals with IBD. A deeper understanding of the complex links between diet and the gut microbiome offers vital insights into the pathogenesis of IBD and encourages the creation of novel therapeutic approaches. This article reviews the current literature on the interaction between diet, probiotics, and gut microbiota in maintaining gut homeostasis.