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Öğe Antibacterial Characteristics of Nanofiber Structures Obtained by Benzalkonium Chloride Additive Poly (Vinyl Alcohol)/Gelatin(2019) Yolay, Onur; Yüksek, Metin; Tezcan, Erdem; İşgören, Erkan; Saltık, DeryaPolyvinyl alcohol (PVA) is a hydrophilous and semi-crystallized. It has attracted much relevancy due to its pretty chemical endurance, finethermal determination, decent physical specialities, wonderful bio-compatibility and cheapness. Gelatin (G) is a natural polymer and thatare interesting materials for biomedical applications. Electrospinning is a simple method that provides very porous nanofiber productionwith high surface area. It is possible to produce biomedical, filtration, energy storage and protective materials by using electrospinningmethod. Benzalkonium chloride (BAC) is a kind of anti-microbial cationic surface-active agent, which has been pretty used in merchantwound dressings and has a powerful status toward Gr+ bacteria.In this study, nanofibers were produced from electrospinning of BAC, PVA and G containing solutions at various concentrations. The fibersof obtained nanofiber structure were uniform, continuous and intensive. The optimum parameters in terms of good mechanical and antibacterialproperties were determined. S2 sample, electrospun from 11.63% PVA + 1.0% G +1.0% BAC containing solution, had the bestmorphological and mechanical properties due to having the thinnest fiber diameter (51±13nm) and the highest vertical strength (4.299MPa)and horizontal strength (4.058MPa). It also had antibacterial activity against all the bacteria tested (E. coli, P. aeruginosa, B. subtilis andS. aureus). Due to owning good mechanical and antibacterial properties, S2 sample can have many uses in medical sector.Öğe ANTIBACTERIAL PROPERTIES OF COTTON FABRICS TREATED WITH 8-HYDROXYQUINOLINE AND BORAX(Cbu Research Inst S R O, 2018) Buyukakinci, Banu Yesim; Tezcan, Erdem8-Hydroxyquinoline (8HQ) is a metal chelating agent that also has antibacterial properties against several different bacterial specie, but its use in cotton textile fabrics has not been tested before. 8HQ may be an alternative to heavy metal-based applications for antibacterial textile fabrics therefore, the aim of this research paper was to investigate the antibacterial properties of 8HQ and borax (BX) treated cotton fabrics for the medical textile industry. The homogenous distribution of the treated chemicals was confirmed with SEM/EDX imaging. The antibacterial activities of the fabrics were also tested against Escherichia coli and Staphylococcus aureus bacteria by mimicking the ISO 20645:2004 Standard Test Method. The highest antibacterial property was observed with the 8HQ+BX (8HB) treated cotton samples. Therefore, the 8HB treated cotton products have a potential for use especially in the medical fields mainly due to the absence of heavy metals and bacterial growth.Öğe Application for dissolution of coronary atherosclerotic plaque: a new treatment?(Elsevier Ireland Ltd, 2023) Yolay, Onur; Kasapbaşı, Esat; Öztürk, Volkan; Tezcan, Erdem; Karaoğlu, Hülya; Küçük, C.; Hazıroğlu, Ceyhun; Olcay, Ayça[Abstract Not Available]Öğe Multiple Non-Essential Transition Metals Are Accumulated in Carotid Atherosclerotic Plaques: Missing Link in Atherosclerosis?(Humana Press Inc, 2019) Olcay, Ayhan; Tezcan, Erdem; Canturk, Emir; Inan, Bekir; Karaoglu, Hasan; Kucuk, Ceyhun; Akdemir, BarisPopulation studies revealed that metal exposure through food, environment, and smoking was related with increased risk of cardiovascular disease. In this study, we determined complex chemical elements in surgical carotid endarterectomy specimens and carotid tissues from autopsies without atherosclerosis. Atherosclerotic plaques from 41 endarterectomies and normal carotid tissue from 30 autopsies were collected and elemental composition was determined by inductively coupled plasma optical emission spectrometry (ICP-OES) method. Eleven (26.8%) patients never smoked in carotid endarterectomy group. One patient was brass souvenir worker and one was goldsmith and others did not have direct contact with metals in the carotid endarterectomy group. Na, Cu, Mn, Bi, Co, Mo, Ni, Pb, Sb, Se, Sn, Ti, and W levels were not different between two groups. Bi, Co, Mo, Pb, Ti, and W were below the detection limit of ICP-OES in both groups. Concentrations of Mg, K, Ca, P, Fe, B, Zn, Al, As, Cr, Pt, and Hg were significantly higher in carotid endarterectomies than normal carotid tissue samples. Cd and S values were significantly higher in autopsy samples. There is significant multiple non-essential transition metal accumulation in atherosclerotic carotid endarterectomy plaques. The cardiovascular consequences of metal toxicity have not been researched adequately due to large emphasis on the role of cholesterol in atherosclerosis. High level of non-essential transition metal elements in the carotid atherosclerotic plaques may add the missing link of atherogenesis and may necessitate new treatment and prevention strategies in carotid disease if confirmed by further research.Öğe Stenotic aortic valves have high metal and lack selenium: a new toxic inflammation hypothesis?(Elsevier Ireland Ltd, 2022) Olcay, A.; Albayrak, S. B.; Yolay, O.; Öztürk, V.; Cantürk, E.; Tezcan, Erdem; Karaoğlu, H....
