Determination of cortisol hormone from sweat samples and interpretation with microcontroller

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dc.contributor.authorÇapan, Muhammed Ertuğrul
dc.contributor.authorCingöz, Ebru
dc.contributor.authorÖncel, Hasan Uğur
dc.contributor.authorArıcan, Ercan
dc.date.accessioned2025-02-09T14:33:05Z
dc.date.available2025-02-09T14:33:05Z
dc.date.issued2024
dc.departmentFakülteler, Sağlık Bilimleri Fakültesi, İş Sağlığı ve Güvenliği Bölümü
dc.departmentFakülteler, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümü
dc.description.abstractCortisol, known as the body's stress hormone, regulates metabolism, inflammation, and the immune system. It affects various bodily systems such as the nervous, immune, cardiovascular, respiratory, reproductive, and musculoskeletal systems. Normal sweat cortisol levels range from 8 to 142 ng/ml, with elevated levels indicating stress (200 ng/ml in women, 500 ng/ml in men). This study focuses on colorimetric cortisol analysis using a microfluidic layer to collect sweat samples. Samples are mixed with a specific color reagent. Cortisol levels are quantitatively analyzed using Z-Score values and RGB channel density via photographs taken with the ESP 32 module. The aim is to determine cortisol levels, aiding in diagnosing conditions like Cushing's syndrome and Addison's Disease, leveraging wearable technology. The developed system integrates a microcontroller into the wearable microfluidic system for cortisol measurements throughout the day. Data is displayed and recorded on a computer for streamlined cortisol monitoring. The blue tetrazolium method used offers stable colors and rapid reactions (10 minutes). The Limit of Detection (LOD) is 0.3 ug/mL, with a detection limit of 1.1 ug/mL. Combined with the ESP 32 Cam module, the system detects cortisol concentrations from 0.8 – 60 ug/mL.
dc.description.sponsorshipThis study was supported within the scope of ISTANBUL GEDIK University BAP Graduate Thesis Project numbered BAP.FR.25. This study was supported within the scope of ISTANBUL University BAP Graduate Thesis Project numbered FYL-2022-38254 Project Id 38254.
dc.identifier.doi10.17798/bitlisfen.1470481
dc.identifier.endpage658
dc.identifier.issn2147-3129
dc.identifier.issn2147-3188
dc.identifier.issue3
dc.identifier.startpage646
dc.identifier.urihttps://hdl.handle.net/11501/1731
dc.identifier.urihttps://doi.org/10.17798/bitlisfen.1470481
dc.identifier.volume13
dc.institutionauthorÇapan, Muhammed Ertuğrul
dc.institutionauthorÖncel, Hasan Uğur
dc.institutionauthorid0000-0001-9398-7171
dc.institutionauthorid0000-0002-6900-1955
dc.language.isoen
dc.publisherBitlis Eren University
dc.relation.ispartofBitlis Eren University Journal of Science
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_DergiPark_20250209
dc.subjectMicrofluidic
dc.subjectCortisol Hormone
dc.subjectMicrocontrollers
dc.subjectColorimetirc Analaysis
dc.titleDetermination of cortisol hormone from sweat samples and interpretation with microcontroller
dc.typeArticle

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