Duloxetine and pregabalin in neuropathic pain of lung cancer patients

Basit Öğe Kaydı
dc.authorscopusid54385293400
dc.authorscopusid54385824600
dc.authorscopusid55253131000
dc.contributor.authorGül, Ş.K.
dc.contributor.authorTepetam, H.
dc.contributor.authorGül, H.L.
dc.date.accessioned2024-06-13T20:15:56Z
dc.date.available2024-06-13T20:15:56Z
dc.date.issued2020
dc.departmentİstanbul Gedik Üniversitesi
dc.description.abstractIntroduction: Neuropathic pain occurs in 1% of the population and is difficult to manage. This chronic pain causes psychological distress and impacts patient's quality of life, especially in cancer patients. The aim of this study was to show and compare the efficacy of pregabalin and duloxetine, which are reported in the group of first-line treatment at European Federation of Neurological Societies (EFNS) guidelines on the pharmacological treatment of neuropathic pain (2010 revision) in lung cancer patients by using visual analogue scale (VAS) and Leeds Assessment of Neuropathic Symptoms and Sign (LANSS). Patients and Methods: A prospective, randomized, open label, 3 month of study was conducted. A total of 44 patients that were diagnosed with neuropathic pain (14 women and 30 men) were included in the study. Patient's LANSS and VAS values were recorded before treatment. Then, 22 patients undergo pregabalin and 22 patients undergo duloxetine therapy. But due to side effects (dizziness, constipation), two patients had stopped to use pregabalin. Their LANSS and VAS values were recorded after 1 and 3 months of therapy. Results: When we compare LANSS and VAS scores before treatment, after 1 and 3 months of treatment with pregabalin and duloxetine, a significant decrease was observed in both groups at the 1 and 3 months (p <.01). Duloxetine is superior to pregabalin in reducing the LANSS scores when we compare two groups. Conclusions: Both duloxetine and pregabalin are effective in the treatment of neuropathic pain of lung cancer patients. And as far as we know, this is the first study comparing the efficacy of duloxetine and pregabalin in the neuropathic pain of lung cancer patients. © 2020 The Authors. Brain and Behavior published by Wiley Periodicals, Inc.
dc.identifier.doi10.1002/brb3.1527
dc.identifier.issn2162-3279
dc.identifier.issue3
dc.identifier.pmid31967742
dc.identifier.scopus2-s2.0-85078733035
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1002/brb3.1527
dc.identifier.urihttps://hdl.handle.net/11501/970
dc.identifier.volume10
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherJohn Wiley and Sons Ltd
dc.relation.ispartofBrain and Behavior
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectcancer
dc.subjectduloxetine
dc.subjectefficacy
dc.subjectneuropathic pain
dc.subjectpregabalin
dc.subjectduloxetine
dc.subjectpregabalin
dc.subjectanalgesic agent
dc.subjectduloxetine
dc.subjectpregabalin
dc.subjectadult
dc.subjectaged
dc.subjectArticle
dc.subjectcancer patient
dc.subjectclinical article
dc.subjectcomparative effectiveness
dc.subjectconstipation
dc.subjectcontrolled study
dc.subjectdizziness
dc.subjectfemale
dc.subjecthuman
dc.subjectlung cancer
dc.subjectmale
dc.subjectneuropathic pain
dc.subjectopen study
dc.subjectpractice guideline
dc.subjectprospective study
dc.subjectrandomized controlled trial
dc.subjectvisual analog scale
dc.subjectcancer pain
dc.subjectcomplication
dc.subjectlung tumor
dc.subjectmiddle aged
dc.subjectneuralgia
dc.subjectpain measurement
dc.subjectquality of life
dc.subjecttreatment outcome
dc.subjectvery elderly
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectAnalgesics
dc.subjectCancer Pain
dc.subjectDuloxetine Hydrochloride
dc.subjectFemale
dc.subjectHumans
dc.subjectLung Neoplasms
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectNeuralgia
dc.subjectPain Measurement
dc.subjectPregabalin
dc.subjectProspective Studies
dc.subjectQuality of Life
dc.subjectTreatment Outcome
dc.titleDuloxetine and pregabalin in neuropathic pain of lung cancer patients
dc.typeArticle

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu