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Öğe The boundary value problem for an ordinary linear half-order differential equation(E.A. Buketov Karaganda University Publish House, 2024) Aliyev, Nihan; Rasulov, Mahir; Sinsoysal, BahaddinThis study is devoted to the study of the solution of a boundary value problem for an ordinary linear differential equation of half order with constant coefficients. Using of the fundamental solution of the main part of the considered equation, we obtained the principal relations, from which we obtain the necessary conditions for the Fredholm property of the original problem. Further, using the Mittag-Leffler function, a general solution of the homogeneous equation is obtained. Finally, the problem under consideration is reduced to an integral Fredholm equation of the second kind with a non-singular kernel, i.e., the Fredholm property of the stated problem is proved.Öğe Investigation of the network made with the complementary motor of the thalamus with the DTI method in individuals with tinnitus(Kare Publishing, 2024) Elpen Karyemez, Pınar; Yağımlı, Mustafa; Tozan, HakanObjectives:This This study aimed to investigate the differences in the networks between the thalamus and the supplementary motor area in brain MRI examinations of individuals with subjective chronic tinnitus and healthy control groups. Methods: In the study, brain MRI imaging was performed on 47 patients suffering from bilateral tinnitus for two years or more and 42 healthy individuals. The tensor information obtained using the diffusion tensor imaging sequence data obtained from both groups was processed in the DSI Studio program. Brain connection maps were obtained from the data obtained. Quantitative information of the individual connecogram maps of each case was recorded and the groups were compared. Results: In the tinnitus group, there is an increase in the pathways between the thalamus and the supplementary motor area. In addition, it was determined that the pathways of the thalamus with the hippocampus, superior and middle occipital area and frontal area increased, and the pathways with the hippocampus and cerebellum decreased. Conclusion: Important functions of the supplementary motor area and thalamus; These are cognitive actions in which attention plays an important role, such as noticing the stimulus from the environment, planning and implementing the response action. It is thought that changes in the pathways between the thalamus and the supplementary motor area will especially affect attention-related functions.Öğe Effect of administering kefir on the changes in fecal microbiota and symptoms of inflammatory bowel disease: a randomized controlled trial(AVES, 2019) Yılmaz, İlkay; Dolar, M. Enver; Özpınar, HaydarBackground/Aims: Kefir is a kind of fermented probiotic dairy product. The objective of the present study was to investigate the effects of kefir consumption on the fecal microflora and symptoms of patients with inflammatory bowel disease (IBD). Materials and Methods: Kefir was serially diluted and inoculated into de Man, Rogosa, and Sharpe agar and incubated at 37 degrees C for 48 to 72 h under anaerobic conditions. This was a single-center, prospective, open-label randomized controlled trial. Forty-five patients with IBD were classified into two groups: 25 for treatment and 20 for control. A 400 mL/day kefir was administered to the patients for 4 weeks day and night. Their stool Lactobacillus, Lactobacillus kefiri, content was quantitated by real-time quantitative polymerase chain reaction before and after consumption. Abdominal pain, bloating, stool frequency, stool consistency, and feeling good scores were recorded in diaries daily by the patients. Results: A 5x10(7) CFU/mL count of lactic acid bacteria colony forming units was found in a kefir sample as the total average count. Lactobacillus bacterial load of feces of all subjects in the treatment group was between 10(4) and 10(9) CFU/g, and the first and last measurements were statistically significant (p=0.001 in ulcerative colitis and p=0.005 in Crohn's disease (CD)). The L. kefiri bacterial load in the stool of 17 subjects was measured as between 10(4) and 10(6) CFU/g. For patients with CD, there was a significant decrease in erythrocyte sedimentation rate and C-reactive protein, whereas hemoglobin increased, and for the last 2 weeks, bloating scores were significantly reduced (p=0.012), and feeling good scores increased (p=0.032). Conclusion: According to our data, kefir consumption may modulate gut microbiota, and regular consumption of kefir may improve the patient's quality of life in the short term.Öğe Genetics of randomly bred cats support the cradle of cat domestication being in the Near East(Springernature, 2022) Nilson, Sara M.; Gandolfi, Barbara; Grahn, Robert A.; Kurushima, Jennifer D.; Lipinski, Monika J.; Randi, Ettore; Waly, Nashwa E.; Özpınar, Haydar; Lyons, Leslie A.Cat domestication likely initiated as a symbiotic relationship between wildcats (Felis silvestris subspecies) and the peoples of developing agrarian societies in the Fertile Crescent. As humans transitioned from hunter-gatherers to farmers similar to 12,000 years ago, bold wildcats likely capitalized on increased prey density (i.e., rodents). Humans benefited from the cats' predation on these vermin. To refine the site(s) of cat domestication, over 1000 random-bred cats of primarily Eurasian descent were genotyped for single-nucleotide variants and short tandem repeats. The overall cat population structure suggested a single worldwide population with significant isolation by the distance of peripheral subpopulations. The cat population heterozygosity decreased as genetic distance from the proposed cat progenitor's (F.s. lybica) natural habitat increased. Domestic cat origins are focused in the eastern Mediterranean Basin, spreading to nearby islands, and southernly via the Levantine coast into the Nile Valley. Cat population diversity supports the migration patterns of humans and other symbiotic species.
