Synthesis and controlled release of curcumin-β-cyclodextrin inclusion complex from nanocomposite poly(N-isopropylacrylamide/sodium alginate) hydrogels

Basit Öğe Kaydı
dc.contributor.authorKasapoğlu Çalık, Meltem
dc.contributor.authorÖzdemir, Murat
dc.date.accessioned2024-06-13T20:17:47Z
dc.date.available2024-06-13T20:17:47Z
dc.date.issued2019
dc.departmentMeslek Yüksekokulu, Gedik Meslek Yüksekokulu, Kimya Teknolojisi Programı
dc.description.abstractInclusion complex of curcumin with beta-cyclodextrin (Cur-beta-CD) was prepared using coprecipitation method. Stoichiometric ratio between curcumin and beta-cyclodextrin was found to be 1:2 with an association constant of 3.80 x 10(8) M-2 using Benesi-Hildebrand method. Inclusion complex formation was confirmed by FTIR and DSC analyses. Water solubility of curcumin increased from 0.00122 to 0.721 mg mL(-1) with the inclusion complex formation. Release of the inclusion complex from the nanocomposite and conventional poly(N-isopropylacrylamide/sodium alginate hydrogels crosslinked by nanoclay and N,N '-methylenebis(acrylamide) (BIS), respectively, were investigated in simulated gastrointestinal conditions. Swelling ratio and cumulative release were dependent on the hydrogel composition and pH. At pH = 1.2, hydrogels showed the lowest release ratio, but at pH = 6.8 highest swelling ratios were attained. The swelling ratio and cumulative release decreased with increasing the nanoclay content in nanocomposite hydrogels. On the contrary, as the ratio of BIS in the conventional hydrogels increased, the swelling ratio and cumulative release increased.
dc.identifier.doi10.1002/app.47554
dc.identifier.issn0021-8995
dc.identifier.issn1097-4628
dc.identifier.issue21
dc.identifier.scopus2-s2.0-85060614721
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1002/app.47554
dc.identifier.urihttps://hdl.handle.net/11501/1054
dc.identifier.volume136
dc.identifier.wosWOS:000459320700010
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorKasapoğlu Çalık, Meltem
dc.institutionauthorid0000-0001-5851-0714
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Applied Polymer Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.relation.tubitakinfo:eu-repo/grantAgreement/TUBITAK/SOBAG/BIDEB 2211-C
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCurcumin
dc.subjectDrug Delivery
dc.subjectHydrogel
dc.subjectInclusion Complex
dc.subjectPnipa
dc.subjectSodium Alginate
dc.subjectBeta-Cyclodextrin
dc.titleSynthesis and controlled release of curcumin-β-cyclodextrin inclusion complex from nanocomposite poly(N-isopropylacrylamide/sodium alginate) hydrogels
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
Tam Metin / Full Text
Boyut:
922.64 KB
Biçim:
Adobe Portable Document Format
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Gedik Meslek Yüksekokulu Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu