Analysis and evaluation of quality parameters of commercial propolis products using a new high Performance Liquid Chromatography (HPLC) method and Comparison of antimicrobial properties

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dc.contributor.authorKaragül, Bora
dc.contributor.authorUğraş, Serpil
dc.contributor.authorKaragül, Pınar
dc.contributor.authorUsta, Mehtap
dc.contributor.authorUğraş, Halil İbrahim
dc.date.accessioned2024-09-05T14:08:05Z
dc.date.available2024-09-05T14:08:05Z
dc.date.issued2024
dc.departmentFakülteler, Mühendislik Fakültesi, Metalurji ve Malzeme Mühendisliği Bölümü
dc.description.abstractPropolis, which has an important place in functional foods, is a natural bee product with high biological active value and is consumed in different formulations and packages worldwide. Thanks to the active compounds it contains, propolis shows biological properties such as antibacterial, antifungal, antiviral, antiprotozoal, antitumoral, antiulcer and anti-inflammatory. However, it is seen that propolis supplements are prepared unconsciously in the market. Such commercial products need to be standardized. Within the scope of this study, characteristic compounds of Turkish propolis were initially determined with support from the literature. Subsequently, bioactive components of 23 commercial propolis products were analyzed using the new HPLC method. Then, the flavonoid content and antimicrobial activity of the samples were determined. According to the results of these analyses, the amounts of Caffeic Acid (2,16-1620,57 ppm, Quercetin (0,19-203,99 ppm), Apigenin (0,30-319,08 ppm), Kaempferol (0,56-251,15 ppm), Chrysin (3,97-2830,93 ppm), and Caffeic Acid Phenethyl Ester (13,08-9666,48 ppm) were found to be quite different. The highest flavonoid content was measured as P2: 20847,43 mg/L and the lowest was 00003,10 mg/L in sample P13. Samples prepared for children were found to be highly diluted in terms of content. Again, it was determined that the samples with high preservation of active ingredients were products with production certificates based on laboratory analyzes. The samples were generally found to have inhibition activity against Gram (+) bacteria. Propolis samples P6 and P22 showed high activity against Gram (+) and Gram (-) bacteria and even fungi. When we evaluated some products that are insufficient in terms of content and antimicrobial activity, it was observed that antimicrobial activity increased depending on the other auxiliary chemicals used in the products. In this context, propolis products, which are very valuable in terms of health, may lose their real activity due to uncontrolled production and will gradually be devalued in the market. It is important that this valuable product should be produced and offered to the market with the necessary analysis methods without losing its effectiveness.
dc.description.sponsorshipDuzce University - BAP- 2021.05.03.1224
dc.identifier.doi10.1016/j.microc.2024.111023
dc.identifier.issn0026-265X
dc.identifier.issn1095-9149
dc.identifier.scopus2-s2.0-85196420098
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://hdl.handle.net/11501/1526
dc.identifier.urihttps://doi.org/10.1016/j.microc.2024.111023
dc.identifier.volume204
dc.identifier.wosWOS:001259323400001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorUğraş, Halil İbrahim
dc.institutionauthorid0000-0002-1633-967X
dc.language.isoen
dc.publisherElsevier Inc.
dc.relation.ispartofMicrochemical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAntimicrobial Activity
dc.subjectBioactive Ingredient
dc.subjectHPLC
dc.subjectPropolis
dc.subjectFlavonoid
dc.subjectCommercial Product
dc.titleAnalysis and evaluation of quality parameters of commercial propolis products using a new high Performance Liquid Chromatography (HPLC) method and Comparison of antimicrobial properties
dc.typeArticle

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