Age-related reduction in oxygen uptake and ventilatory markers among middle-aged adults

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dc.contributor.authorAmer Radhi, Mohammed
dc.contributor.authorShahidi, Seyed Houtan
dc.contributor.authorÇatak, Tuba
dc.contributor.authorAlhusaen Aga, Mohamed T.
dc.date.accessioned2025-12-11T07:22:44Z
dc.date.available2025-12-11T07:22:44Z
dc.date.issued2025
dc.departmentFakülteler, Spor Bilimleri Fakültesi, Antrenörlük Eğitimi Bölümü
dc.departmentFakülteler, Sağlık Bilimleri Fakültesi, Hemşirelik Bölümü
dc.description.abstractBACKGROUND: The objective of this research was to investigate age-related variations in crucial physiological indicators such as relative and absolute VO2, aerobic and anaerobic thresholds, and ventilatory dynamics (VT1 and VT2), across six decades of adulthood, specifically spanning from 20 to 60 years. The objective of this study was to measure the extent to which these markers decrease with age and to assess their possible health consequences. METHODS: The study involved 50 individuals who were divided into four distinct age brackets: 20-30, 30-40, 40-50, and 50-60 years. Physiological data were examined using a combination of parametric statistical tests (ANOVA, Tukey honest significant difference [HSD]) and nonparametric techniques (Kruskal-Wallis). Trends in VO2, threshold behavior, and ventilatory responses were assessed using effect sizes, stepwise comparisons, biexponential modeling, and 95% confidence intervals. RESULTS: The results show a substantial decrease in relative VO2 with increasing age, demonstrating a significant decline (P<0.001) that corresponds to a medium effect size (η²=0.213) and a notable reduction of 35% between the youngest and oldest groups. Participants over the age reached ventilatory thresholds (VT1 and VT2) at lower oxygen usage levels, suggesting decreased aerobic capacity. Absolute VO2 and threshold values declined, but only relative VO2 and weight differences demonstrated statistically significant changes. CONCLUSIONS: Research indicates a significant decrease in cardiovascular and respiratory capacity as people age, notably in relative VO2 and ventilatory thresholds, resulting in the onset of fatigue at an earlier stage and a reduction in an individual’s ability to exercise. Early intervention through tailored aerobic training is crucial for countering performance degradation and decreasing cardiometabolic risk in older individuals, as highlighted by these physiological changes.
dc.identifier.doi10.23736/S0393-3660.25.06192-3
dc.identifier.endpage882
dc.identifier.issn0393-3660
dc.identifier.issue10
dc.identifier.scopus2-s2.0-105023648198
dc.identifier.scopusqualityQ4
dc.identifier.startpage875
dc.identifier.urihttps://doi.org/10.23736/S0393-3660.25.06192-3
dc.identifier.urihttps://hdl.handle.net/11501/2543
dc.identifier.volume184
dc.indekslendigikaynakScopus
dc.institutionauthorAmer Radhi, Mohammed
dc.institutionauthorShahidi, Seyed Houtan
dc.institutionauthorÇatak, Tuba
dc.institutionauthorid0000-0001-5379-3567
dc.institutionauthorid0000-0002-0834-4858
dc.language.isoen
dc.publisherEdizioni Minerva Medica
dc.relation.ispartofGazzetta Medica Italiana Archivio per le Scienze Mediche
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCardiovascular System
dc.subjectHeart Rate
dc.subjectOxygen
dc.titleAge-related reduction in oxygen uptake and ventilatory markers among middle-aged adults
dc.typeArticle

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