The safety profile of aspartame: a review of regulatory standards and emerging health concerns

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dc.contributor.authorÖncel, Hasan Uğur
dc.contributor.authorSökmen, Zehra
dc.date.accessioned2026-04-30T11:31:56Z
dc.date.available2026-04-30T11:31:56Z
dc.date.issued2026
dc.departmentFakülteler, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümü
dc.description.abstractWe reviewed the effects of aspartame, one of the artificial sweeteners widely used in the food industry, on human health. We evaluated the chemical structure, metabolic processes, and potential health effects of aspartame in light of scientific studies. Studies in various health areas, such as cancer risk assessment, effects on the nervous system and cardiovascular system, and its role in metabolic disorders, have led to various debates about the safety of aspartame for human health. While aspartame’s low-calorie structure provides an advantage for metabolic diseases such as obesity and diabetes, its potential effects on insulin sensitivity and gut microbiota have led to different conclusions. In light of the adverse effects of the phenylalanine amino acid in the structure of aspartame on brain development, we have tried to emphasize that consumption levels should be more closely monitored in special risk groups such as phenylketonuria (PKU) patients, children, pregnant women, and the elderly. The widespread use of aspartame in the food industry has led to the view that this structure is safe when consumed as a sweetener at acceptable daily intake levels. This review seeks to answer, “Is it a safe additive for human health when individual sensitivities and long-term effects are considered?”
dc.identifier.doi10.1155/jnme/4727546
dc.identifier.issn2090-0724
dc.identifier.issn2090-0732
dc.identifier.issue1
dc.identifier.pmid42022336
dc.identifier.scopus2-s2.0-105036112843
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1155/jnme/4727546
dc.identifier.urihttps://hdl.handle.net/11501/2695
dc.identifier.volume2026
dc.identifier.wosWOS:001744387200001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakScopus
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.institutionauthorÖncel, Hasan Uğur
dc.institutionauthorSökmen, Zehra
dc.institutionauthorid0000-0002-6900-1955
dc.institutionauthorid0009-0001-4489-8161
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Nutrition and Metabolism
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectArtificial Sweeteners
dc.subjectAspartame
dc.subjectCancer Risk
dc.subjectHuman Health
dc.subjectMetabolic Disorders
dc.subjectNervous System
dc.subjectPhenylalanine
dc.titleThe safety profile of aspartame: a review of regulatory standards and emerging health concerns
dc.typeReview Article

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