Additively manufactured continuous processing reactor system for producing liquid-based pharmaceutical substances

dc.contributor.authorKhabiyev, Alibek
dc.contributor.authorDilibal, Savaş
dc.contributor.authorMussulmanbekova, Assel
dc.contributor.authorKanapiya, Magzhan
dc.contributor.authorKerimkulov, Daniyar
dc.date.accessioned2024-12-02T09:01:04Z
dc.date.available2024-12-02T09:01:04Z
dc.date.issued2024
dc.departmentFakülteler, Mühendislik Fakültesi, Mekatronik Mühendisliği Bölümü
dc.description.abstractIn this study, an AM-based continuous processing reactor system was designed, manufactured, and assembled on a laboratory scale for the generation of pharmaceutical substances with an improved process control. The developed AM-based (additively manufactured) continuous pharmaceutical reactor system for the synthesis of metronidazole derivatives aimed to optimize both the physical and the chemical processes with time savings. Using AM, we were able to build reactor subcomponents with complex designs and precise dimensions, which facilitated the precise control of the reaction parameters and reduced the amount of chemicals required compared to macroscale reactors. The assembly of the whole reactor system consisted of main reactor bodies, mixers, valves, heat exchangers, electrical motors, and a microcontroller system. The assembled reactor system revealed a continuous flow of reagents and ensured uniform mixing and reaction conditions, thereby increasing the process efficiency and product quality. Five metronidazole derivatives were synthesized via two continuous processes, involving metronidazole reduction and its subsequent reactions with terephthalic aldehyde and anthracen-9(10H)-one to form Schiff bases. The optimal conditions were determined as follows: compound A (72% yield, 120 min, 55 °C), compounds B and C (63% and 68% yield, respectively, 8 h, 65 °C), and compounds D and E (74% and 85% yield, respectively, 8 h, 45 °C).
dc.description.sponsorshipGovernment of the Republic of Kazakhstan ; Ministry of Science & Higher Education of the Republic of Kazakhstan ; Science Committee of the Ministry of Science & Higher Education of the Republic of Kazakhstan
dc.identifier.doi10.3390/app14166853
dc.identifier.issn2076-3417
dc.identifier.issue16
dc.identifier.scopus2-s2.0-85202445018
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/app14166853
dc.identifier.urihttps://hdl.handle.net/11501/1571
dc.identifier.volume14
dc.identifier.wosWOS:001305125700001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorDilibal, Savaş
dc.institutionauthorid0000-0003-4777-7995
dc.language.isoen
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.relation.ispartofApplied Sciences (Switzerland)
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAdditive Manufacturing
dc.subjectChemical Processes
dc.subjectContinuous Processing Reactor
dc.subjectMetronidazole Derivatives
dc.subjectReactor Systems
dc.titleAdditively manufactured continuous processing reactor system for producing liquid-based pharmaceutical substances
dc.typeArticle

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