The effect of prophylactic intraoperative tranexamic acid use on bleeding after laparoscopic sleeve gastrectomy with omentopexy: a prospective cohort study

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dc.contributor.authorDalkılıç, Muhammed Said
dc.contributor.authorŞişik, Abdullah
dc.contributor.authorGençtürk, Mehmet
dc.contributor.authorYılmaz, Merih
dc.contributor.authorErdem, Hasan
dc.contributor.authorParmar, Chetan
dc.date.accessioned2025-12-01T12:12:18Z
dc.date.available2025-12-01T12:12:18Z
dc.date.issued2025
dc.departmentFakülteler, Sağlık Bilimleri Fakültesi, Hemşirelik Bölümü
dc.description.abstractBackground Laparoscopic sleeve gastrectomy (LSG) is the most widely performed bariatric procedure. While advancements like staple line reinforcement (SLR) have reduced hemorrhagic complications, bleeding risks persist. Tranexamic acid (TXA), an antifibrinolytic agent, has shown promise in mitigating bleeding risks in various surgical disciplines, but its efficacy in LSG with SLR remains unexplored. This study aims to evaluate the effect of intraoperative TXA administration on postoperative bleeding outcomes in patients undergoing LSG with oversewing and omentopexy.Methods This prospective observational cohort study included 233 patients undergoing LSG with oversewing and omentopexy. Patients were divided into 2 groups: 1 received 1 g of TXA intraoperatively, while the other did not. Hemoglobin differences at 24 and 48 hours postoperatively were the primary outcomes. Secondary outcomes included blood transfusion necessity, re-intervention rates, and 30-day surgical complications.Results There was no statistically significant difference in hemoglobin changes at 24 hours (TXA group: 0.8 +/- 0.7 g/dL, 95% CI: 0.67-0.93; control group: 0.9 +/- 0.9 g/dL, 95% CI: 0.74-1.06; P = 0.125) or at 48 hours (TXA group: 1.4 +/- 1.5 g/dL, 95% CI: 1.12-1.68; control group: 1.5 +/- 1.4 g/dL, 95% CI: 1.25-1.75; P = 0.167) between the groups. No patients required transfusions or re-interventions. Five patients in the control group exhibited hemorrhagic drainage exceeding 150 mL, while none in the TXA group experienced similar complications. Length of hospital stay and operative time were similar between the groups (P = 0.124 and 0.746, respectively).Conclusions Tranexamic acid may not significantly impact major bleeding complications following LSG with oversewing and omentopexy but appears to reduce minor hemorrhagic events.
dc.identifier.doi10.1177/15533506251344055
dc.identifier.endpage416
dc.identifier.issn1553-3506
dc.identifier.issn1553-3514
dc.identifier.issue5
dc.identifier.pmid40418962
dc.identifier.scopus2-s2.0-105007014675
dc.identifier.scopusqualityQ2
dc.identifier.startpage409
dc.identifier.urihttps://doi.org/10.1177/15533506251344055
dc.identifier.urihttps://hdl.handle.net/11501/2519
dc.identifier.volume32
dc.identifier.wosWOS:001497323800001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorŞişik, Abdullah
dc.institutionauthorErdem, Hasan
dc.language.isoen
dc.publisherSAGE Publications Inc.
dc.relation.ispartofSurgical Innovation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBleeding
dc.subjectPostoperative Complication
dc.subjectPostoperative Hemorrhage
dc.subjectSleeve Gastrectomy
dc.subjectTranexamic Acid
dc.titleThe effect of prophylactic intraoperative tranexamic acid use on bleeding after laparoscopic sleeve gastrectomy with omentopexy: a prospective cohort study
dc.typeArticle

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