Frequent object dropping in carpal tunnel syndrome: a consequence of impaired sensorimotor integration?

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dc.contributor.authorMatur, Zeliha
dc.contributor.authorDörtcan, Nimet
dc.contributor.authorİmişçi, Sertaç
dc.contributor.authorSüner, Melis
dc.contributor.authorAcar, Zeynep
dc.contributor.authorSözer, Nejla
dc.contributor.authorÖge, Ali Emre
dc.date.accessioned2025-11-20T08:24:43Z
dc.date.available2025-11-20T08:24:43Z
dc.date.issued2025
dc.departmentFakülteler, Sağlık Bilimleri Fakültesi, Çocuk Gelişimi Bölümü
dc.description.abstractFrequent object dropping is a common complaint in patients with carpal tunnel syndrome (CTS), suggesting potential disruptions in sensorimotor integration. This study investigated the electrophysiological characteristics of sensorimotor integration in CTS patients with and without this symptom. We enrolled twelve CTS patients with frequent object dropping (dCTS), ten CTS patients without noticeable clumsiness (ndCTS), and sixteen healthy controls. All participants underwent clinical evaluation, the Boston Carpal Tunnel Questionnaire, and the Purdue Pegboard Test. To assess sensorimotor integration, electrical stimulation was applied to the median and ulnar nerves, followed by transcranial magnetic stimulation over the contralateral motor cortex at interstimulus intervals (ISIs) of 20, 35, 50, 65, 80, 100, and 200 ms. Motor-evoked potentials (MEPs) were recorded from the thenar and hypothenar muscles. Key findings revealed distinct sensorimotor integration patterns on the dominant side. In the dCTS group, median nerve stimulation at a 35 ms ISI resulted in significantly higher MEP amplitude ratios in the thenar muscles compared to controls. Conversely, in the ndCTS group, ulnar nerve stimulation at ISIs of 20, 80, and 100 ms produced greater MEP ratios in the same muscles. These results demonstrate topographically divergent cortical sensory processing between dCTS and ndCTS patients. One interpretation of these findings is that altered sensorimotor integration from the median nerve underlies the clumsiness in dCTS, while patients without this symptom (ndCTS) may successfully compensate by utilizing sensory input from the ulnar nerve.
dc.identifier.doi10.1016/j.brainres.2025.150029
dc.identifier.issn0006-8993
dc.identifier.pmid41187823
dc.identifier.scopus2-s2.0-105020822092
dc.identifier.scopusqualityN/A
dc.identifier.urihttps://doi.org/10.1016/j.brainres.2025.150029
dc.identifier.urihttps://hdl.handle.net/11501/2505
dc.identifier.volume1869
dc.identifier.wosWOS:001612109300001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakPubMed
dc.indekslendigikaynakScopus
dc.indekslendigikaynakWeb of Science
dc.institutionauthorDörtcan, Nimet
dc.institutionauthorid0000-0001-9004-0492
dc.language.isoen
dc.publisherElsevier B.V.
dc.relation.ispartofBrain Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBoston Carpal Tunnel Questionnaire
dc.subjectCarpal Tunnel Syndrome
dc.subjectFrequent Dropping Objects
dc.subjectLong-Latency Afferent Inhibition
dc.subjectPurdue Pegboard Test
dc.subjectSensorimotor Integration
dc.subjectShort-Latency Afferent Inhibition
dc.titleFrequent object dropping in carpal tunnel syndrome: a consequence of impaired sensorimotor integration?
dc.typeArticle

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