GMFCS level improvement in children with cerebral palsy treated with repeat botulinum toxin injections and intensive rehabilitation: a retrospective study

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dc.contributor.authorDursun, Nigar
dc.contributor.authorAkyüz, Merve
dc.contributor.authorGökbel, Tuğba
dc.contributor.authorAkarsu, Melike
dc.contributor.authorYılmaz, Esin
dc.contributor.authorKaracan, Çağla
dc.contributor.authorDursun, Erbil
dc.date.accessioned2024-06-13T20:18:31Z
dc.date.available2024-06-13T20:18:31Z
dc.date.issued2022
dc.departmentFakülteler, Spor Bilimleri Fakültesi, Antrenörlük Eğitimi Bölümü
dc.description.abstractPURPOSE: The Gross Motor Functional Classification System (GMFCS) provides a standardized classification of motor disability in children with cerebral palsy (CP) that is typically considered longitudinally stable. Here, changes in GMFCS levels of children with CP who received repeated botulinum toxin A (BoNT-A) injections within an intensive rehabilitation approach were evaluated. METHODS: This retrospective, observational study included 503 children with CP (GMFCS I-V) treated in a single university rehabilitation clinic. Individualized treatment plans and a variety of rehabilitation techniques were incorporated within an integrated model of care. Each child received >= 2 repeated BoNT-A injections as well as an intensive rehabilitation program. RESULTS: GMFCS level following repeat treatment improved in 42.1% of the patients and worsened in 3 patients; 14.9% of children showed improvement after 1 treatment cycle, 12.3% after 2 cycles, 7.6% after 3 cycles, 3.6% after 4 cycles, and 3.8% after >= 5 cycles. Type of involvement (p < 0.001), baseline GMFCS (p = 0.001), number of treatment cycles (p < 0.001) and presence of severe dystonia (p = 0.032) were significant predictors of GMFCS improvement, but age and gender were not. CONCLUSION: Children with CP may change GMFCS level when intensive rehabilitation programs are combined with repeated BoNT-A injections.
dc.description.sponsorshipIpsen Pharma; Ipsen (Paris, France)
dc.identifier.doi10.3233/PRM-210013
dc.identifier.endpage112
dc.identifier.issn1874-5393
dc.identifier.issn1875-8894
dc.identifier.issue1
dc.identifier.pmid35275571
dc.identifier.scopus2-s2.0-85128011527
dc.identifier.scopusqualityQ2
dc.identifier.startpage107
dc.identifier.urihttps://doi.org/10.3233/PRM-210013
dc.identifier.urihttps://hdl.handle.net/11501/1418
dc.identifier.volume15
dc.identifier.wosWOS:000778399800012
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKaracan, Çağla
dc.institutionauthorid0000-0002-5607-6675
dc.language.isoen
dc.publisherIOS Press
dc.relation.ispartofJournal of Pediatric Rehabilitation Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCerebral Palsy
dc.subjectGMFCS
dc.subjectBotulinum Toxin
dc.titleGMFCS level improvement in children with cerebral palsy treated with repeat botulinum toxin injections and intensive rehabilitation: a retrospective study
dc.typeArticle

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