Evaluation of vincristine-induced peripheral neuropathy in children with cancer: Turkish validity and reliability study

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dc.contributor.authorÖzdemir, Bilge
dc.contributor.authorÖzalp Gerçeker, Gülçin
dc.contributor.authorÖzdemir, Emine Zahide
dc.contributor.authorYıldırım, Büşra Güliz
dc.contributor.authorÖren, Hale
dc.contributor.authorYis, Uluc
dc.contributor.authorGünay, Çağatay
dc.date.accessioned2024-06-13T20:18:03Z
dc.date.available2024-06-13T20:18:03Z
dc.date.issued2023
dc.departmentMeslek Yüksekokulu, Gedik Meslek Yüksekokulu, Anestezi Programı
dc.description.abstractBackground: The evaluation of peripheral neuropathy in children receiving Vincristine treatment is challenging. This study examined the Turkish validity and reliability of the Total Neuropathy Score-Pediatric Vincristine (TNS-PV) measurement tool, which can measure Vincristine-induced peripheral neuropathy symptoms in children with cancer.Methods: A total of 53 children aged 5-17 years who received Vincristine treatment in two pediatric hematology-oncology centers participated in the study. Data was collected using the Total Neuropathy Score-Pediatric Vincristine (TNS-PV), the Common Terminology Criteria for Adverse Events (CTCAE), the Wong-Baker FACES Pain Scale, and the Adolescent Pediatric Pain Tool (APPT). The correlation between the TNS-PV total score and other scales and the inter-rater reliability coefficient was evaluated.Findings: Of the children, 81.1% were diagnosed with ALL and 13.2% with Ewing Sarcoma. Cronbach's alpha values of form A and B of the TNS-PV scale were 0.628 and 0.639, respectively. As the cumulative Vincristine dose in-creased, the children's scores on TNS-PV were higher. A moderate and significant positive correlation was found between the TNS-PV form A total score and the worst subjective symptoms (a, b) (A), strength, tendon reflexes, and autonomic / constipation (r = 0.441, r = 0.545, r = 0.472, r = 0.536, p < 0.01). Discussion: The TNS-PV form B total score was found to have a moderate level, significant correlation with CTCAE sensory neuropathy score and Wong-Baker FACES Pain Scale, and a high level, significant positive correlation with CTCAE motor neuropathy score.Application to practice: The TNS-PV is valid and reliable for measuring Vincristine-induced peripheral neuropathy in practice in Turkish children 5 years and older.
dc.identifier.doi10.1016/j.pedn.2023.04.006
dc.identifier.endpage190
dc.identifier.issn0882-5963
dc.identifier.pmid37076371
dc.identifier.scopus2-s2.0-85152730139
dc.identifier.scopusqualityQ1
dc.identifier.startpage185
dc.identifier.urihttps://doi.org/10.1016/j.pedn.2023.04.006
dc.identifier.urihttps://hdl.handle.net/11501/1199
dc.identifier.volume72
dc.identifier.wosWOS:001104640100001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÖzdemir, Bilge
dc.language.isoen
dc.publisherElsevier Science Inc
dc.relation.ispartofJournal of Pediatric Nursing-Nursing Care of Children & Families
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPeripheral Neuropathy
dc.subjectChild
dc.subjectCancer
dc.subjectChemotherapy
dc.subjectValidity
dc.subjectPatterns
dc.subjectPain
dc.titleEvaluation of vincristine-induced peripheral neuropathy in children with cancer: Turkish validity and reliability study
dc.typeArticle

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