Multiple non-essential transition metals are accumulated in carotid atherosclerotic plaques: missing link in atherosclerosis?

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dc.contributor.authorOlcay, Ayhan
dc.contributor.authorTezcan, Erdem
dc.contributor.authorCantürk, Emir
dc.contributor.authorİnan, Bekir
dc.contributor.authorKaraoğlu, Hasan
dc.contributor.authorKüçük, Ceyhun
dc.contributor.authorAkdemir, Barış
dc.date.accessioned2024-06-13T20:17:51Z
dc.date.available2024-06-13T20:17:51Z
dc.date.issued2019
dc.departmentFakülteler, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümü
dc.description.abstractPopulation studies revealed that metal exposure through food, environment, and smoking was related with increased risk of cardiovascular disease. In this study, we determined complex chemical elements in surgical carotid endarterectomy specimens and carotid tissues from autopsies without atherosclerosis. Atherosclerotic plaques from 41 endarterectomies and normal carotid tissue from 30 autopsies were collected and elemental composition was determined by inductively coupled plasma optical emission spectrometry (ICP-OES) method. Eleven (26.8%) patients never smoked in carotid endarterectomy group. One patient was brass souvenir worker and one was goldsmith and others did not have direct contact with metals in the carotid endarterectomy group. Na, Cu, Mn, Bi, Co, Mo, Ni, Pb, Sb, Se, Sn, Ti, and W levels were not different between two groups. Bi, Co, Mo, Pb, Ti, and W were below the detection limit of ICP-OES in both groups. Concentrations of Mg, K, Ca, P, Fe, B, Zn, Al, As, Cr, Pt, and Hg were significantly higher in carotid endarterectomies than normal carotid tissue samples. Cd and S values were significantly higher in autopsy samples. There is significant multiple non-essential transition metal accumulation in atherosclerotic carotid endarterectomy plaques. The cardiovascular consequences of metal toxicity have not been researched adequately due to large emphasis on the role of cholesterol in atherosclerosis. High level of non-essential transition metal elements in the carotid atherosclerotic plaques may add the missing link of atherogenesis and may necessitate new treatment and prevention strategies in carotid disease if confirmed by further research.
dc.identifier.doi10.1007/s12011-018-1481-0
dc.identifier.endpage425
dc.identifier.issn0163-4984
dc.identifier.issn1559-0720
dc.identifier.issue2
dc.identifier.pmid30120677
dc.identifier.scopus2-s2.0-85052496799
dc.identifier.scopusqualityQ1
dc.identifier.startpage420
dc.identifier.urihttps://doi.org/10.1007/s12011-018-1481-0
dc.identifier.urihttps://hdl.handle.net/11501/1115
dc.identifier.volume189
dc.identifier.wosWOS:000465432600013
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorTezcan, Erdem
dc.institutionauthorid0000-0001-7379-9931
dc.language.isoen
dc.publisherHumana Press Inc
dc.relation.ispartofBiological Trace Element Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAtherosclerosis
dc.subjectEndarterectomy
dc.subjectNon-Essential Transition Metal
dc.subjectHeavy Metal
dc.titleMultiple non-essential transition metals are accumulated in carotid atherosclerotic plaques: missing link in atherosclerosis?
dc.typeArticle

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