Ocular effects of synthetic cannabinoids: a case-control study

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dc.contributor.authorKunduracı, Merve Sena
dc.contributor.authorKırık, Furkan
dc.contributor.authorOnur, İsmail Umut
dc.contributor.authorŞahmelikoğlu Onur, Özge
dc.contributor.authorKarşıdağ, Çağatay
dc.contributor.authorYiğit, Fadime Ulviye
dc.contributor.authorErkıran, Murat
dc.date.accessioned2025-05-30T08:30:16Z
dc.date.available2025-05-30T08:30:16Z
dc.date.issued2025
dc.departmentFakülteler, İktisadi, İdari ve Sosyal Bilimler Fakültesi, Psikoloji Bölümü
dc.description.abstractObjective: To evaluate the ocular effects of "Bonzai", a synthetic cannabinoid (SC), in seropositive and seronegative users. Methods: Sixty eyes of 60 consecutive male patients with a history of "Bonzai" use and 30 eyes of 30 age-matched male healthy controls were enrolled in this case-control study. Patients with past "Bonzai" use were grouped as seropositive (n:30) and seronegative (n:30) according to urine toxicology tests. All groups were compared for blood pressures, intraocular pressure, foveal and parafoveal retinal thicknesses, subfoveal and parafoveal choroidal thicknesses, measurements of the peripapillary retinal nerve fibre layer (RNFL), and macular ganglion cell complex (GCC), subfoveal total choroidal, luminal and stromal areas, and choroidal vascularity index (CVI). Results: No differences were noted in blood pressures between the groups (p > 0.05). The mean intraocular pressure was significantly lower in the seropositive group than in the other groups (p < 0.001). Foveal and retinal thicknesses, RNFL, and GCC measurements did not differ between the groups (p > 0.05). Subfoveal and parafoveal choroidal thicknesses and areas were lower in the seropositive group than in the other groups (p < 0.001, for all). CVI increased in both groups with "Bonzai" use compared to the control group (p < 0.001, for all). Conclusions: This study indicates that intraocular pressure may decrease, and choroidal changes may be observed in SC users. Further clinical studies with a larger sample size, especially using purified SC for therapeutic purposes, are needed to confirm the present findings, and further histopathologic studies are required to clarify the changes in the choroid despite SC seronegativity.
dc.identifier.doi10.1038/s41433-024-03381-x
dc.identifier.endpage101
dc.identifier.issn0950-222X
dc.identifier.issn1476-5454
dc.identifier.issue1
dc.identifier.pmid39375488
dc.identifier.scopus2-s2.0-85205912004
dc.identifier.scopusqualityQ1
dc.identifier.startpage94
dc.identifier.urihttps://doi.org/10.1038/s41433-024-03381-x
dc.identifier.urihttps://hdl.handle.net/11501/2113
dc.identifier.volume39
dc.identifier.wosWOS:001330500800001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakPubMed
dc.indekslendigikaynakScopus
dc.indekslendigikaynakWeb of Science
dc.institutionauthorKarşıdağ, Çağatay
dc.language.isoen
dc.publisherSpringer Nature
dc.relation.ispartofEye (Basingstoke)
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectSynthetic Cannabinoids
dc.subjectOcular Effects
dc.subjectControl Study
dc.titleOcular effects of synthetic cannabinoids: a case-control study
dc.typeArticle

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