Efficacy of ursodeoxycholic acid in reducing the necessity of cholecystectomy due to pre-existing and subsequently formed gallstones in patients who underwent laparoscopic sleeve gastrectomy

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dc.contributor.authorDemirpolat, Muhammed Taha
dc.contributor.authorÇelikkaya, Muhammet Oğuz
dc.contributor.authorErtekin, Süleyman Çağlar
dc.contributor.authorBaşak, Fatih
dc.contributor.authorŞişik, Abdullah
dc.date.accessioned2025-02-04T13:45:50Z
dc.date.available2025-02-04T13:45:50Z
dc.date.issued2025
dc.departmentFakülteler, Sağlık Bilimleri Fakültesi, Hemşirelik Bölümü
dc.description.abstractBackgroundIn this study, we aimed to investigate whether ursodeoxycholic acid (UDCA) would reduce the necessity of cholecystectomy in patients diagnosed with asymptomatic gallstones after laparoscopic sleeve gastrectomy (LSG) and in patients diagnosed with asymptomatic gallstones before LSG.MethodsBetween July 2020 and November 2022, at least 2-year follow-ups of patients who underwent LSG for obesity were retrospectively analyzed. Patients with pre-existing asymptomatic gallstones during preoperative evaluation, those with UDCA treatment (group 1), and observation group (group 2). Patients with newly formed gallstones in postoperative outpatient clinic follow-up, those with UDCA treatment (group A), and those without UDCA treatment (group B).ResultsA total of 425 patients included. At the end of the first year, patients who had newly formed gallstones after LSG had a higher total weight loss percentages (TWL%) (39.8 +/- 6.1) compared to those who did not develop gallstones (37.9 +/- 7.4), which were statistically significant (p = 0.004). Among patients who developed gallstones postoperatively, UDCA treatment was associated with a significantly lower cholecystectomy rate in patients with newly formed gallstones postoperatively (p = 0.025), while no significant difference was shown in patients with preoperative gallstones (p = 0.631).ConclusionUDCA is a promising option for reducing the need for cholecystectomy in patients with post-LSG gallstones, but it appears ineffective for pre-existing gallstones.
dc.identifier.doi10.1186/s12893-025-02767-2
dc.identifier.issn1471-2482
dc.identifier.issue1
dc.identifier.pmid39825346
dc.identifier.scopus2-s2.0-85216225045
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1186/s12893-025-02767-2
dc.identifier.urihttps://hdl.handle.net/11501/1608
dc.identifier.volume25
dc.identifier.wosWOS:001401080500002
dc.identifier.wosqualityQ2
dc.indekslendigikaynakPubMed
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorŞişik, Abdullah
dc.institutionauthorid0000-0002-7500-8651
dc.language.isoen
dc.publisherBMC
dc.relation.ispartofBMC Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectUrsodeoxycholic Acid
dc.subjectGallstones
dc.subjectLaparoscopic Sleeve Gastrectomy
dc.subjectThe Necessity of Cholecystectomy
dc.titleEfficacy of ursodeoxycholic acid in reducing the necessity of cholecystectomy due to pre-existing and subsequently formed gallstones in patients who underwent laparoscopic sleeve gastrectomy
dc.typeArticle

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