Electrospun PVA/CS/HA/BA nanofiber scaffolds with enhanced mechanical stability and antifungal activity for bone tissue engineering

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dc.contributor.authorYavuz, Yağızer
dc.contributor.authorKartal, İlyas
dc.contributor.authorCesur, Sümeyye
dc.contributor.authorKanlı, Zehra
dc.contributor.authorKaya, Elif
dc.contributor.authorTinaz, Gülgün
dc.contributor.authorGündüz, Oğuzhan
dc.date.accessioned2026-02-09T13:21:37Z
dc.date.available2026-02-09T13:21:37Z
dc.date.issued2026
dc.departmentMeslek Yüksekokulu, Gedik Meslek Yüksekokulu, Tahribatsız Muayene Programı
dc.description.abstractIn this study, we created multifunctional bone tissue engineering scaffolds that combine prophylactic antifungal action with structural support. We produced PVA/CS/HA/BA nanofiber matrices via a specifically designed electrospinning technique to stop early cross-linking. Through SEM, our examination of fiber shape revealed diameters ranging from 178 +/- 53 nm to 330 +/- 69 nm. We discovered that this variation was closely correlated with the Boric Acid (BA) level. Our EDS and FTIR studies further showed that HA and BA were effectively mixed, with a specific focus on the production of borate-ester linkages inside the network. Mechanical examination revealed that 0.25 wt.% BA maximizes the tensile strength at 9.15 MPa, thereby closely matching HA-reinforced standards, while HA incorporation improved thermal stability. Moreover, in vitro hFOB experiments showed sustained cytocompatibility at 0.25 wt.% BA. While 0.5 wt.% BA showed strong antifungal action against Candida albicans, it sadly harmed cell viability. The 0.25 wt.% BA concentration ultimately offers a better balance between mechanical integrity and antibacterial action, therefore presenting a potential method for scaffold generation for bone regeneration in immunocompromised patients.
dc.description.sponsorshipMarmara University ; FDK-2024-11223
dc.identifier.doi10.3390/ma19020412
dc.identifier.issn1996-1944
dc.identifier.issue2
dc.identifier.pmid41598123
dc.identifier.scopus2-s2.0-105029085860
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/ma19020412
dc.identifier.urihttps://hdl.handle.net/11501/2616
dc.identifier.volume19
dc.identifier.wosWOS:001671153900001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYavuz, Yağızer
dc.language.isoen
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.relation.ispartofMaterials
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAntifungal Scaffolds
dc.subjectCandida Albicans
dc.subjectCross-Linking Behavior
dc.subjectScaffold
dc.titleElectrospun PVA/CS/HA/BA nanofiber scaffolds with enhanced mechanical stability and antifungal activity for bone tissue engineering
dc.typeArticle

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