New vitamin K3 (menadione) analogues: synthesis, characterization, antioxidant and catalase inhibition activities
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Tarih
2020
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Indian Academy of Sciences
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In this study, derivatives of new vitamin K3 were synthesized by the reactions of 2-methyl-1,4-naphthoquinone1with some heterocyclic ring substituted nucleophiles: 1-piperonylpiperazine2, 1-(2-furoyl)piperazine5, 1-(2-aminoethyl)piperidine8, 1-(2-aminoethyl)pyrrolidine10and 2,6-dimethyl morpholine12in chloroform/triethylamine (TEA) or ethanol at room temperature. Their structures were characterized by Fourier transform infrared spectroscopy (FT-IR),H-1 nuclear magnetic resonance (H-1 NMR), attached proton test nuclear magnetic resonance (APT-NMR) and mass spectrometry (MS). Newly synthesized vitamin K3 derivatives (3,4,6,7,9,11,13,14) have shown catalase inhibition activity and compound 13 has displayed remarkable potency against catalase enzyme. These compounds were also tested for their antioxidant capacity in vitro by CUPRAC method.
Açıklama
Anahtar Kelimeler
Vitamin K3 (Menadione), Heterocyclic Ring, Cuprac Method, Catalase Inhibition Activity
Kaynak
Journal of Chemical Sciences
WoS Q Değeri
Q3
Scopus Q Değeri
Q3
Cilt
132
Sayı
1