New vitamin K3 (menadione) analogues: synthesis, characterization, antioxidant and catalase inhibition activities

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Küçük Resim

Tarih

2020

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Indian Academy of Sciences

Erişim Hakkı

info:eu-repo/semantics/closedAccess

Özet

In this study, derivatives of new vitamin K3 were synthesized by the reactions of 2-methyl-1,4-naphthoquinone1with some heterocyclic ring substituted nucleophiles: 1-piperonylpiperazine2, 1-(2-furoyl)piperazine5, 1-(2-aminoethyl)piperidine8, 1-(2-aminoethyl)pyrrolidine10and 2,6-dimethyl morpholine12in chloroform/triethylamine (TEA) or ethanol at room temperature. Their structures were characterized by Fourier transform infrared spectroscopy (FT-IR),H-1 nuclear magnetic resonance (H-1 NMR), attached proton test nuclear magnetic resonance (APT-NMR) and mass spectrometry (MS). Newly synthesized vitamin K3 derivatives (3,4,6,7,9,11,13,14) have shown catalase inhibition activity and compound 13 has displayed remarkable potency against catalase enzyme. These compounds were also tested for their antioxidant capacity in vitro by CUPRAC method.

Açıklama

Anahtar Kelimeler

Vitamin K3 (Menadione), Heterocyclic Ring, Cuprac Method, Catalase Inhibition Activity

Kaynak

Journal of Chemical Sciences

WoS Q Değeri

Q3

Scopus Q Değeri

Q3

Cilt

132

Sayı

1

Künye