New vitamin K3 (menadione) analogues: synthesis, characterization, antioxidant and catalase inhibition activities

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dc.contributor.authorDeniz, Nahide Gülşah
dc.contributor.authorAbdassalam, Aesha F. S. H.
dc.contributor.authorÖzyürek, Mustafa
dc.contributor.authorYeşil, Emin Ahmet
dc.contributor.authorSayıl, Çiğdem
dc.date.accessioned2024-06-13T20:17:51Z
dc.date.available2024-06-13T20:17:51Z
dc.date.issued2020
dc.departmentMeslek Yüksekokulu, Gedik Meslek Yüksekokulu, Kimya Teknolojisi Programı
dc.description.abstractIn this study, derivatives of new vitamin K3 were synthesized by the reactions of 2-methyl-1,4-naphthoquinone1with some heterocyclic ring substituted nucleophiles: 1-piperonylpiperazine2, 1-(2-furoyl)piperazine5, 1-(2-aminoethyl)piperidine8, 1-(2-aminoethyl)pyrrolidine10and 2,6-dimethyl morpholine12in chloroform/triethylamine (TEA) or ethanol at room temperature. Their structures were characterized by Fourier transform infrared spectroscopy (FT-IR),H-1 nuclear magnetic resonance (H-1 NMR), attached proton test nuclear magnetic resonance (APT-NMR) and mass spectrometry (MS). Newly synthesized vitamin K3 derivatives (3,4,6,7,9,11,13,14) have shown catalase inhibition activity and compound 13 has displayed remarkable potency against catalase enzyme. These compounds were also tested for their antioxidant capacity in vitro by CUPRAC method.
dc.description.sponsorshipIstanbul University-Cerrahpasa [FDK-2017-24871, FBA-2019-30472, FBA-2019-32783]
dc.identifier.doi10.1007/s12039-020-01835-9
dc.identifier.issn0974-3626
dc.identifier.issn0973-7103
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85092284568
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1007/s12039-020-01835-9
dc.identifier.urihttps://hdl.handle.net/11501/1116
dc.identifier.volume132
dc.identifier.wosWOS:000576171500001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorYeşil, Emin Ahmet
dc.institutionauthorid0000-0001-8559-1951
dc.language.isoen
dc.publisherIndian Academy of Sciences
dc.relation.ispartofJournal of Chemical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectVitamin K3 (Menadione)
dc.subjectHeterocyclic Ring
dc.subjectCuprac Method
dc.subjectCatalase Inhibition Activity
dc.titleNew vitamin K3 (menadione) analogues: synthesis, characterization, antioxidant and catalase inhibition activities
dc.typeArticle

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