Could DTI unlock the mystery of subjective tinnitus: it's time for parameters that go a little out of the routine

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dc.contributor.authorYılmaz, Eren
dc.contributor.authorYıldırım, Düzgün
dc.contributor.authorTekcan Şanlı, Deniz Esin
dc.contributor.authorElpen, Pınar
dc.contributor.authorGösterişli Tüzüner, Filiz
dc.contributor.authorGökmen İnan, Neslihan
dc.contributor.authorŞirin, Ahmet
dc.contributor.authorYağımlı, Mustafa
dc.contributor.authorTozan, Hakan
dc.contributor.authorŞanlı, Ahmet Necati
dc.contributor.authorKandemirli, Sedat Giray
dc.date.accessioned2024-12-02T10:06:05Z
dc.date.available2024-12-02T10:06:05Z
dc.date.issued2024
dc.departmentFakülteler, Mühendislik Fakültesi, Bilgisayar Mühendisliği Bölümü
dc.description.abstractIn this study, it was aimed to assess the microstructural changes in the main central auditory pathway in cases with subjective tinnitus. In total, 101 subjects (52 cases with bilateral subjective non-pulsatile tinnitus and 49 healthy cases as the control group) were included in the study. Participants underwent pure tone audiogram and Diffusion Tensor Imaging-Magnetic Resonance Imaging (DTI-MRI) examination with a 3 Tesla MRI device. The number of tracts, tract length, volume, and quantitative anisotropy (QA) and normalized quantitative anisotropy' (nQA) values were calculated by plotting cochleocortical pathways from the cochlear nerve to ipsilateral and contralateral Heschl's gyrus (HG). In pure tone audiometry, the control group had lower hearing thresholds than cases with tinnitus. Fibres and nQA values from the right cochlear nerve to the right HG were significantly lower in the tinnitus group than in the control group. Cochlear nuclei voxel counts were significantly decreased in the tinnitus group. Both cochlear nucleus volumes were higher in the tinnitus group than in the control group. nQA values in both cochlear nuclei were decreased in the tinnitus group. This study showed that the most commonly affected part in subjective non-pulsatile tinnitus cases is the cochlear nucleus. Therefore, the cochlear nucleus should be evaluated more carefully in cases presenting with subjective tinnitus.
dc.identifier.doi10.1007/s12070-024-04963-7
dc.identifier.endpage5284
dc.identifier.issn2231-3796
dc.identifier.issn0973-7707
dc.identifier.issue6
dc.identifier.pmid39559082
dc.identifier.scopus2-s2.0-85202495787
dc.identifier.scopusqualityQ3
dc.identifier.startpage5277
dc.identifier.urihttps://doi.org/10.1007/s12070-024-04963-7
dc.identifier.urihttps://hdl.handle.net/11501/1572
dc.identifier.volume76
dc.identifier.wosWOS:001299705500003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorElpen, Pınar
dc.institutionauthorYağımlı, Mustafa
dc.institutionauthorid0000-0003-4113-8308
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofIndian Journal of Otolaryngology and Head and Neck Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCochlear Nucleus
dc.subjectDiffusion Tensor Imaging
dc.subjectTinnitus
dc.titleCould DTI unlock the mystery of subjective tinnitus: it's time for parameters that go a little out of the routine
dc.typeArticle

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